| Place | Name | | Affiliation | Time | | | Heat (Pl) |
|---|
| 1 | Candace Hill | 17 | Rockdale County Tc-Ga-Girls | 11.46 | Q | +1.9 | 1 (1) |
| 2 | Jayla Kirkland | 17 | Una-Al-Birmingha-Hawkins` | 11.53 | Q | +1.8 | 3 (1) |
| 3 | Kate Hall | 15 | Una-Me-Casco-Hall | 11.58 | q | +1.8 | 3 (2) |
| 4 | Brenessa Thompson | 15 | Medgar Evers College Prep | 11.60 | Q | +0.8 | 4 (1) |
| 5 | Diamond Spaulding | 15 | Aquinas Tc-Fl | 11.71 | q | +0.8 | 4 (2) |
| 6 | Mikiah Brisco | 14 | Baton Rouge Tc-La | 11.72 | Q | +1.2 | 2 (1) |
| 7 | Sekayi Bracey | 16 | Kentwood Tc-Mi | 11.74 | q | +0.8 | 4 (3) |
| 8 | Carolyn Brown | 15 | Phoebus Tc-Va | 11.75 | q | +1.9 | 1 (2) |
| 9 | Zola Golden | 15 | Arlington Tc-Ny | 11.78 | | +0.8 | 4 (4) |
| 10 | Lakayla Harris | 15 | Northwestern Tc-Fl | 11.82 | | +1.2 | 2 (2) |
| 11 | Katlin Sherman | 15 | Mustang Tc-Nc | 11.83 (11.822) | | +1.8 | 3 (3) |
| 12 | Tamara Clark | 17 | High Point Heat-NC | 11.83 (11.823) | | +1.2 | 2 (3) |
| 13 | Torie Robinson | 14 | Winslow Elite Tc-Nj | 11.87 | | +1.9 | 1 (3) |
| 14 | Caitland Smith | 14 | Una-Al-Birmingham-Adams | 11.88 | | +1.2 | 2 (4) |
| 15 | Raven Grant | 15 | Una-Sc-Conway-Thomas | 11.89 (11.888) | | +1.9 | 1 (4) |
| 16 | Kaysha Love | 16 | Triple Crown Tc-Nv | 11.89 (11.889) | | +1.2 | 2 (5) |
| 17 | Janel Pate | 15 | Trainng Ground Tc-Tn | 11.91 (11.903) | | +1.8 | 3 (4) |
| 18 | Sydnei Murphy | 15 | Bull City Express-NC | 11.91 (11.904) | | +0.8 | 4 (5) |
| 19 | Akua Obeng-Akrofi | 14 | Una-Ga-Lawre-Obeng-Akrofi | 11.94 | | +0.8 | 4 (6) |
| 20 | Cedrina Singletary | 15 | Young Achievers Sc-Fl | 11.96 (11.951) | | +1.9 | 1 (5) |
| 21 | Bria Saunders | 14 | Una-Nj-Parsippan-Saunders | 11.96 (11.953) | | +1.8 | 3 (5) |
| 22 | Morgan Towe | 16 | Kempsville Tc-Va | 12.01 | | +1.8 | 3 (6) |
| 23 | Kiara Lester | 16 | Deptford Tc-Nj | 12.12 | | +1.9 | 1 (6) |
| 24 | Jessica Scott | 14 | Hopkinton Tc-Ma | 12.21 (12.201) | | +0.8 | 4 (7) |
| 25 | Martha Sam | 15 | 5-Star-Blake-Va | 12.21 (12.210) | | +1.9 | 1 (7) |
| 26 | Chanel Smith | 14 | Piscataway Tc-Nj | 12.33 | | +1.2 | 2 (6) |
| 27 | Maiya Dendy | 15 | Lightning Fast Tc-De | 12.87 | | +1.8 | 3 (7) |
| Shalon Conley | 14 | Pickerington Tc-Oh | DNS | | | 2 |