| Place | Name | | Affiliation | Time | | | Heat (Pl) |
|---|
| 1 | Trentavis Friday | 14 | GJ Tc-Nc | 20.48 | Q | +0.6 | 3 (1) |
| 2 | Noah Lyles | 16 | TC Williams Tc-A | 20.82 | Q | -0.5 | 4 (1) |
| 3 | Ryan Clark | 15 | Star Track Tc-Ga | 20.98 | Q | +0.6 | 2 (1) |
| 4 | Darryl Haraway | 15 | DeMatha Catholic Tc-Md | 21.00 | q | -0.5 | 4 (2) |
| 5 | QuaShawn Cunningham | 14 | Mallard Creek Tc-Nc | 21.04 | q | +0.6 | 2 (2) |
| 6 | Ivy Dobson | 14 | Triple Crown Esc Tc-Nv | 21.12 | q | +0.6 | 2 (3) |
| 7 | Carrington Akosa | 14 | Beastly Wolverines-MD | 21.21 | q | +0.6 | 3 (2) |
| 8 | Ricky Morgan | 14 | Una-Va-Woodbridge-Morgan | 21.27 | | +0.6 | 2 (4) |
| 9 | Josephus Lyles | 16 | TC Williams Tc-A | 21.30 | Q | +1.8 | 1 (1) |
| 10 | Robert Grant | 14 | Una-Az-Phoenix-Grant | 21.41 | | +1.8 | 1 (2) |
| 11 | Jaylen Bacon | 14 | Lower Richland Tc-Sc | 21.52 (21.516) | | +1.8 | 1 (3) |
| 11 | Maxwell Willis | 16 | Bowie Tc-Md | 21.52 (21.516) | | +0.6 | 3 (3) |
| 13 | Malcolm Johnson | 14 | Southview Tc-Oh | 21.56 | | +0.6 | 2 (5) |
| 14 | Tosin Oyewole | 14 | Long Reach Tc-Md | 21.62 | | +1.8 | 1 (4) |
| 15 | Chris Estrella | 14 | Ridgefield Park Tc-Nj | 21.70 | | +1.8 | 1 (5) |
| 16 | Maurice Allen | 14 | Motor City Tc-Mi | 21.72 | | +1.8 | 1 (6) |
| 17 | Justin Lewis | 14 | Una-Nv-Las_vegas-Lewis | 21.82 | | +0.6 | 3 (4) |
| 18 | Semasa Oni | 14 | Medgar Evers College Prep | 21.84 | | +0.6 | 2 (6) |
| 19 | Grant Swinton | 14 | Star Track Tc-Ga | 21.97 | | -0.5 | 4 (3) |
| 20 | Dondre Mimms | 14 | Apollo Tc-Ky | 21.98 | | +1.8 | 1 (7) |
| 21 | Xavier Smith | 14 | Daniel Boone Tc-Pa | 22.04 (22.033) | | -0.5 | 4 (4) |
| 22 | Travis Collins | 14 | Velocity Sun Athletics-GA | 22.04 (22.035) | | -0.5 | 4 (5) |
| 23 | Michael Davenport | 16 | Una-Nc-Winston-Salem-Hill | 22.11 | | +0.6 | 3 (5) |
| 24 | Cornelius Scott | 15 | North Cobb Tc-Ga | 22.16 | | +0.6 | 2 (7) |
| Leon Powell | 14 | Kennedale Tc-Tx | DNS | | | 1 |
| Darius Watkins | | Velocity Track Academy-GA | DNS | | | 2 |
| Jaalen Jones | 14 | Una-Al-Maylene-Jones | DNS | | | 4 |
| Gerald Mills | 15 | Una-Tx-Missouri_cit-Mills | DNS | | | 4 |
| Brandon Reddick | 14 | Una-Fl-Orlando-Reddick | DNS | | | 4 |
| Christian Coleman | 14 | Una-Ga-Atlanta-Coleman | DQ | | | 3 |
| Travis Johnson | 14 | Montgomery Dream Team-AL | DNS | | | 3 |